Radiology MRI

  There are many congenital anomalies of the spine. One rare is this one spotted as incidental finding on MRI of the Cervical Spine of a 64 years old patient. Reporting radiologist pointed skeletal anomaly in form of an ossicle between laminae of C2 and C3 on the right side causing slight impression on the posterior part of the dural sack, recommending further analysis with CT of the Cervical Spine. The CT has confirmed what looks like an anomalous ossicle between laminae C2 and C3. The ossicle has its own cortex and there are some depressions in the laminae due to its presence.  Similar anomalous ossicle is described in T. Keats - Atlas of Normal Roentgen Variants 7th edition, Figure 3-69, page 215. 

  As a funny post here example of counting spinal levels by AI (Artificial Intelligence - purple) vs Human (me - orange). :)

Remember my old post about anatomy of the Internal Acoustic Canal (ICA). I mentioned that to me it looks like " Monkey Looking at Cerebellum " in cross section. Mouth of the monkey being Vestibular Nerve and upper eye being 7th nerve (Facial Nerve) (7-UP!) and lower eye being Cochlear Nerve.  Today I came across this exam showing a Small Vestibular Schwannoma (VS) deep in the Internal Acoustic Canal.  Note that the VS is located in the "mouth" of the monkey.  This is a section just next to the VS showing a bit "sad face of the monkey". :(

  A person with known in family KRIT-1 gene mutation shows multiple (uncountable number) cavernous malformations (cavernomas) on the SWI sequence (most to the left on both images). The largest one located temporo-occipital in the right hemisphere (to the left on the images) is visible on T2 sequence and hardly noticeable on T1 without and with Gd contrast. Other multiple cavernomas are hard to spot on other sequences. Same situation in the posterior fossa.  According to the literature:  "The KRIT1 gene (also known as CCM1) provides instructions for making a protein that strengthens the interactions between cells that form blood vessels and limits leakage from the vessels."    https://medlineplus.gov/genetics/gene/krit1/ "Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures."    https://pubmed.ncb

  Coronal CT of 86 years old showing moderate atrophy i hippocampi - MTA 2. Interesting articles indicate complex relation between our gut flora and neurodegenerative diseases. Especially in Alzheimer Dementia (AD). Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease - Peilin Sun, Et al. Downregulation of Neurofilament Light Chain Expression in Human Neuronal-Glial Cell Co-Cultures by a Microbiome-Derived Lipopolysaccharide-Induced miRNA-30b-5p - Aileen I. Pogue, Et al. *(citations from above articles in cursive font) Studies indicate that anaerobic bacteria producing toxins cause brain inflammation that disrupts fragile neural connections in the elderly. My private theory is that hygiene of the mouth plays important role. Environmental factors of the modern civilisation, food preservatives and destruction of natural gut flora plays important role. Also fact that people live longer allows more time for neurodegenerative diseases to develop. O

  Large Colloid Cyst in the roof of the Third Ventricle in Cavum Vergae - posteriorly in the Third Ventricle.  As usual there is no enhancement. CT with contrast shows higher attenuation due to cholesterol component of the fluid (mucin) in the cyst. Note higher than CSF signal on FLAIR and T2. There is no hydrocephalus and no oedema. You can compare it to other Large Colloid Cyst  expanding more anteriorly and the most typical in size and location  Colloid Cyst  - in the roof of the Third Ventricle near Foramina Monroi. Note small "dots" on the superior aspect of the Colloid Cyst representing Internal Cerebral Veins - that are not compromised.