CLIPPERS - Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids

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T1 GD+ sequences show multiple punctate and linear enhancing lesions in pons and medulla oblongata representing perivascular enhancing lymphatic tissue.


Enhancing punctate lesions are also present in corona radiata on both sides. FLAIR sequence showing corresponding white matter lesions that however present no significant oedema.

Findings represent CLIPPERS - Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Rare entity caused by infiltration of the brain with inflammatory cells in perivascular areas, mostly found in brainstem.

More comprehensive description of CLIPPERS in Radiopaedia



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